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Community Health Network's board-certified hepatobiliary surgery specialists have more than 20 years of experience treating liver, gallbladder, bile duct and pancreatic cancers and related diseases. Our cancer experts are Community Health Network MD Anderson Cancer Center participating providers, offering patients access to innovative cancer treatments close to home in Central Indiana.
Learn more about our specialists:
To make an appointment for hepatobiliary cancer treatment or other needs, please call our office at 317-621-3970 or call Community's oncology scheduling specialists at 317-621-2627.
The hepatobiliary (HPB) system of the human body includes your liver, gall bladder and bile ducts. Because the pancreas is so closely connected to these organs, it is often treated by the same specialist teams. Cancers can affect all the organs in the HPB system. Learn more about these cancers below.
The liver is the largest organ inside the body, located in the upper right side of the abdomen below the right lung. It removes toxins and waste from the body and produces bile to help with digestion.
Primary liver cancer is the sixth most common cancer and a leading cause of cancer-related deaths globally, with more than 42,340 new cases expected to be diagnosed in the U.S. in 2026.
While anyone can develop liver cancer, certain medical conditions and lifestyle factors can significantly elevate your risk:
In its early stages, liver cancer may not cause noticeable warning signs. As the tumor grows, common symptoms include:
Living a healthy lifestyle can help reduce your risk of developing liver cancer:
Yes, if caught early, liver cancer is treatable and potentially curable. Your specialized care team will customize a plan based on your overall liver health and the stage of the disease, which may include:
Gallbladder cancer is a relatively rare disease. The gallbladder is a small, pear-shaped organ located below the liver, behind the ribs. Its primary function is to store and release bile produced by the liver to assist with digestion.
While it plays a role in your digestive system, the gallbladder is not an essential organ—patients can continue to live a full, healthy life if it is removed.
While the exact cause isn't always known, certain demographic trends and health conditions can elevate your risk:
In its early stages, gallbladder cancer may not cause noticeable symptoms. As it progresses, patients might experience:
If you are diagnosed, your multidisciplinary care team will build a personalized plan tailored to your specific stage. Treatment for gallbladder cancer typically includes one or a combination of the following:
Bile duct cancer, also known clinically as cholangiocarcinoma, is a rare disease that forms in the slender tubes that carry the digestive fluid bile from your liver and gallbladder into the small intestine.
According to the American Cancer Society, approximately 8,000 people in the United States develop bile duct cancer each year.
Because bile ducts are small, even a tiny tumor can block the flow of bile, often causing noticeable symptoms earlier than some other hepatobiliary cancers:
Treating bile duct cancer requires a highly coordinated, multidisciplinary approach. Depending on the location and stage of the tumor, your care team may recommend:
Pancreatic cancer begins in the tissues of your pancreas—an organ located horizontally behind the lower part of your stomach. The pancreas plays a vital role in your health by secreting enzymes that aid digestion and producing hormones that help manage your blood sugar.
Because pancreatic cancer often develops quietly and can grow or spread rapidly, symptoms typically do not appear until the disease has reached an advanced stage. This rapid progression is why it is currently the fourth leading cause of cancer-related deaths in the United States, with more than 67,530 people expected to be diagnosed in 2026.
Tumors are categorized based on the type of pancreatic cells they originate in:
While the exact underlying causes are still being studied, several health conditions, lifestyle choices, and genetic factors can elevate risk:
Because pancreatic tumors require highly sophisticated management, your multidisciplinary care team will customize a plan based on the tumor's stage and precise location. Treatment may include:
Because the liver, gallbladder and bile ducts are closely connected, early signs of a problem often include jaundice (yellowing of the eyes or skin), unexplained upper abdominal pain on the right side, chronic fatigue and changes in the color of your urine (darker) or stool (lighter or clay-colored). If you notice these symptoms, you should consult a doctor right away.
Diagnosing tumors in the hepatobiliary system usually requires a combination of advanced imaging and lab work. Your care team may order blood tests (including liver function tests and tumor markers), imaging scans like an MRI, CT or ultrasound, or a specialized endoscopic procedure (like an ERCP) to look inside the bile ducts and take a tissue sample if needed.
While most cases happen without a family history, genetics can play a role. Certain inherited gene mutations — such as the BRCA1 or BRCA2 mutations associated with pancreatic cancer, or hereditary conditions like Lynch syndrome and hemochromatosis — can increase your baseline risk. If you have a strong family history of these conditions, our team can help coordinate genetic counseling.
